| ncRNA name | HOXA11-AS |
| ncRNA Category | lncRNA |
| ID | 221883 |
| Ensembl | ENSG00000240990 |
| Synonyms | HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM samples; UM cell lines OCM-1A, MUM-2C, C918 and MUM-2B; melanocyte cell line D78 |
| Methods | qRT-PCR, transfection, CCK-8 assay, transwell assay, flow cytometry, luciferase reporter assay, Western blot, RNA immunoprecipitation, Chromatin immunoprecipitation |
| Expression pattern | up-regulated |
| Functional description | RNA immunoprecipitation demonstrated that HOXA11-AS could simultaneously interact with enhancer of zeste homolog 2 (EZH2) to suppress its target p21 protein expression. In addition, we demonstrated that HOXA11-AS functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS. |
| PubMed ID | 28749709 |
| Year | 2017 |
| Title | LncRNA HOXA11-AS Exerts Oncogenic Functions by Repressing p21 and miR-124 in Uveal Melanoma. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.